Journal
CELL
Volume 146, Issue 6, Pages 873-887Publisher
CELL PRESS
DOI: 10.1016/j.cell.2011.08.039
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Funding
- Federal Government Belgium [IUAP06/30]
- Flemish Government, a Concerted Research Activities Belgium [GOA2006/11]
- The Research Foundation-Flanders [FWO G.0673.08]
- Foundation Leducq Transatlantic Network ARTEMIS
- Deutsche Forschungsgemeinschaft (DFG) [SFB 834/A6, Exc 147/1]
- Cancer Research UK
- Lister Institute of Preventive Medicine
- EMBO
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Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and they contribute to disease progression. Therapeutic approaches to block vascular supply have reached the clinic, but limited efficacy and resistance pose unresolved challenges. Recent insights establish how endothelial cells communicate with each other and with their environment to form a branched vascular network. The emerging principles of vascular growth provide exciting new perspectives, the translation of which might overcome the current limitations of pro- and antiangiogenic medicine.
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