Journal
NATURE REVIEWS IMMUNOLOGY
Volume 3, Issue 1, Pages 63-72Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri982
Keywords
-
Categories
Ask authors/readers for more resources
Immunoglobulin A is the most abundant immunoglobulin isotype in mucosal secretions. In this review, we summarize recent advances in our understanding of the sites, mechanisms and functions of intestinal IgA synthesis in mice. On the basis of these recent findings, we propose an updated model for the induction and regulation of IgA responses in the gut. In addition, we discuss new insights into the role of IgA in the maintenance of gut homeostasis and into the reciprocal interactions between gut B cells and the bacterial flora.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available