Journal
CELL
Volume 147, Issue 2, Pages 271-274Publisher
CELL PRESS
DOI: 10.1016/j.cell.2011.09.010
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [R21 AI084633-02, R21 AI084633] Funding Source: Medline
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Two groups have identified SAMHD1, a protein encoded by an Aicardi-Goutie` res Syndrome susceptibility gene, as the factor that restricts infection of macrophages and dendritic cells with HIV-1. Here we discuss implications of this discovery for induction of antiviral protective immunity.
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