Journal
CANCER GENETICS AND CYTOGENETICS
Volume 140, Issue 1, Pages 73-77Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0165-4608(02)00631-3
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Rhabdomyosarcomas (RMS) are soft tissue sarcomas resembling developing skeletal muscle, and pleomorphic rhabdomyosarcomas (PRMS) are a rare nonpediatric entity. Little molecular cytogenetic information exists for PRMS, and their relationship to other subtypes of rhabdomyosarcoma and other sarcomas is unclear. Chromosomal imbalances were determined in seven well-characterized cases of PRMS using comparative genomic hybridization. The smallest overlapping regions of gain were 1p22similar top33 (71%), 7p (43%), 18/18q (43%), and 20/20p (43%), and the regions of loss were 10q23 (71%), 15q21similar toq22 (57%), 3p, 5q32similar toqter, and 13 (all 43%). Four of the seven cases had amplicons involving the regions 1p21similar top31, 1q21similar toq25, 3p12, 3q26similar toqtel, 4q28similar toq31, 8q21similar toq23/8q, and 22q. These regions are distinct from those frequently associated with the alveolar subtype, whereas the embryonal subtype without anaplasia is rarely associated with amplification events other than gain/amplification of 8q material. The regions of imbalance appeared more similar to those reported for malignant fibrous histiocytomas (MFH) and osteosarcomas, consistent with the suggestion that PRMS can be considered part of the spectrum of MFH. In addition, one of the cases classified as PRMS showed evidence for the presence of a PAX3-FOXO1A fusion gene, which is characteristic of the alveolar subtype of RMS. (C) 2003 Elsevier Science Inc. All rights reserved.
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