Journal
CELL
Volume 144, Issue 6, Pages 844-849Publisher
CELL PRESS
DOI: 10.1016/j.cell.2011.03.008
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Funding
- National Institutes of Health [R01 GM073010-01]
- Office of Science, Office of Biological and Environmental Research of the US Department of Energy [DE-AC02-05CH11231]
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A decade ago, seminal perspectives and papers set a strong vision for the field of systems biology, and a number of these themes have flourished. Here, we describe key technologies and insights that have elucidated the evolution, architecture, and function of cellular networks, ultimately leading to the first predictive genome-scale regulatory and metabolic models of organisms. Can systems approaches bridge the gap between correlative analysis and mechanistic insights?
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