Journal
ANTIVIRAL RESEARCH
Volume 57, Issue 1-2, Pages 147-150Publisher
ELSEVIER
DOI: 10.1016/S0166-3542(02)00207-3
Keywords
influenza A virus/H5N1 viruses/reverse genetics/antiviral drugs
Categories
Funding
- NIAID NIH HHS [AI 11772] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI011772, R01AI011772] Funding Source: NIH RePORTER
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Influenza A virus has been responsible for widespread human epidemics because it is readily transmitted from humans to humans by aerosol. Recent events have highlighted the potential of influenza A virus as a bioterrorist weapon: the high virulence of the influenza A virus that infected people in Hong Kong in 1997; and the development of laboratory methods to generate influenza A viruses by transfection of DNAs without a helper virus. Antiviral drugs that are directed at functions shared by all influenza A viruses constitute the best line of defense against a bioterrorist attack. Consequently, new antiviral drugs need to be developed, and the few currently available antiviral drugs should be stockpiled. (C) 2002 Elsevier Science B.V. All fights reserved.
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