Sulfur: Its clinical and toxicologic aspect's

Although there is no known dietary requirement for inorganic sulfur, it is an essential element for all, animal species in-as much as they all require the sulfur-containing amino acid methionine. There are three predominate forms of organic sulfur in animals and humans: 1) the thiomethyl of methionine residues in protein; 2) the sulfhydryl disulfides of protein; and 3) the compounds containing ester or amide bound sulfates of glycosaminoglycans, steroids, and many xenobiotic metabolites., Thus, sulfur becomes an important constituent of amino acids, proteins, enzymes' vitamins and other biomolecules. Unlike mammalian species, plants can use inorganic sulfur and synthesize methionine from, which are synthesized all the other important sulfur compounds. Hence,. sulfur deficiency occurs mainly when plants are grown in sulfur-depleted soils and when humans and animals consume low-protein diets. In recent times, however, the increasing prevalence of refining petroleum, and, smelting sulfur compounds of metallic minerals into free metals are having a large impact on the,balance of sulfur in the environment. Sulfur toxicity is associated mainly with high levels of the element and its toxic volatile substances-in the environment. Sulfur dioxide (SO2), a major air pollutant, may adversely affect animal and human health by causing bronchitis, bronchoconstriction, and increased pulmonary resistance. (C)Elsevier Science Inc. 2003.