Journal
CELL
Volume 141, Issue 2, Pages 344-354Publisher
CELL PRESS
DOI: 10.1016/j.cell.2010.03.031
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Funding
- European Research Council
- European Commission
- FP6 Programme
- Ben May Charitable Trust
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Recent years have seen intensive progress in measuring protein translation. However, the contributions of coding sequences to the efficiency of the process remain unclear. Here, we identify a universally conserved profile of translation efficiency along mRNAs computed based on adaptation between coding sequences and the tRNA pool. In this profile, the first similar to 30-50 codons are, on average, translated with a low efficiency. Additionally, in eukaryotes, the last similar to 50 codons show the highest efficiency over the full coding sequence. The profile accurately predicts position-dependent ribosomal density along yeast genes. These data suggest that translation speed and, as a consequence, ribosomal density are encoded by coding sequences and the tRNA pool. We suggest that the slow ramp'' at the beginning of mRNAs serves as a late stage of translation initiation, forming an optimal and robust means to reduce ribosomal traffic jams, thus minimizing the cost of protein expression.
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