Journal
CELL
Volume 142, Issue 4, Pages 517-518Publisher
CELL PRESS
DOI: 10.1016/j.cell.2010.08.002
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Immune cells and cells activated by the inflammatory cytokine interferon express variant proteasomes called immunoproteasomes that are characterized by unique catalytic subunits. Seifert et al. (2010) now show in mouse models of inflammatory disease that immunoproteasomes help prevent the accumulation of harmful protein aggregates.
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