Journal
CELL
Volume 140, Issue 5, Pages 631-642Publisher
CELL PRESS
DOI: 10.1016/j.cell.2010.01.032
Keywords
-
Categories
Funding
- University of California, Lawrence Berkeley National Laboratory [DE-AC02-05CH11231]
- Lawrence Livermore National Laboratory [DE-AC52-07NA27344]
- Los Alamos National Laboratory [DE-AC02-06NA25396]
- Royal Society University
- Wellcome Trust
- U. of Alberta
Ask authors/readers for more resources
Genome sequences of diverse free-living protists are essential for understanding eukaryotic evolution and molecular and cell biology. The free-living amoebo-flagellate Naegleria gruberi belongs to a varied and ubiquitous protist clade (Heterolobosea) that diverged from other eukaryotic lineages over a billion years ago. Analysis of the 15,727 protein-coding genes encoded by Naegleria's 41 Mb nuclear genome indicates a capacity for both aerobic respiration and anaerobic metabolism with concomitant hydrogen production, with fundamental implications for the evolution of organelle metabolism. The Naegleria genome facilitates substantially broader phylogenomic comparisons of free-living eukaryotes than previously possible, allowing us to identify thousands of genes likely present in the pan-eukaryotic ancestor, with 40% likely eukaryotic inventions. Moreover, we construct a comprehensive catalog of amoeboid-motility genes. The Naegleria genome, analyzed in the context of other protists, reveals a remarkably complex ancestral eukaryote with a rich repertoire of cytoskeletal, sexual, signaling, and metabolic modules.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available