Journal
NATURE IMMUNOLOGY
Volume 4, Issue 1, Pages 78-86Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni872
Keywords
-
Categories
Ask authors/readers for more resources
CD4(+) T cell priming under T helper type I (T(H)1) or T(H)2 conditions gives rise to polarized cytokine gene expression. We found that in these conditions human naive T cells acquired stable histone hyperacetylation at either the Ifng or Il4 promoter. Effector memory T cells showed polarized cytokine gene acetylation patterns in vivo, whereas central memory T cells had hypoacetylated cytokine genes but acquired polarized acetylation and expression after appropriate stimulation. However, hypoacetylation of the nonexpressed cytokine gene did not lead to irreversible silencing because most T(H)1 and T(H)2 cells acetylated and expressed the alternative gene when stimulated under opposite T-H conditions. Such cytokine flexibility was absent in a subset of T(H)2 cells that failed to upregulate T- bet and to express interferon- when stimulated under T(H)1 conditions. Thus, most human CD4(+) T cells retain both memory and flexibility of cytokine gene expression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available