Journal
CELL
Volume 142, Issue 3, Pages 387-397Publisher
CELL PRESS
DOI: 10.1016/j.cell.2010.06.036
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Funding
- University of Sydney
- National Health and Medical Research Council
- Australian Research Council
- Deutsche Forschungsgemeinschaft
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Alzheimer's disease (AD) is characterized by amyloid-beta (A beta) and tau deposition in brain. It has emerged that A beta toxicity is tau dependent, although mechanistically this link remains unclear. Here, we show that tau, known as axonal protein, has a dendritic function in postsynaptic targeting of the Src kinase Fyn, a substrate of which is the NMDA receptor (NR). Missorting of tau in transgenic mice expressing truncated tau (Delta tau) and absence of tau in tau(-/-) mice both disrupt postsynaptic targeting of Fyn. This uncouples NR-mediated excitotoxicity and hence mitigates A beta toxicity. Delta tau expression and tau deficiency prevent memory deficits and improve survival in A beta-forming APP23 mice, a model of AD. These deficits are also fully rescued with a peptide that uncouples the Fyn-mediated interaction of NR and PSD-95 in vivo. Our findings suggest that this dendritic role of tau confers A beta toxicity at the postsynapse with direct implications for patho-genesis and treatment of AD.
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