Journal
CELL
Volume 140, Issue 6, Pages 935-950Publisher
CELL PRESS
DOI: 10.1016/j.cell.2010.02.043
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Categories
Funding
- NIH [AI 15614, CA 6934]
- JDRF [26-2008-893]
- Royal Netherlands Academy of Arts and Sciences
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Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammatory disorders, neurodegenerative disease, or cancer. A variety of safe and effective anti-inflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories, with many more drugs under development. In particular, the new era of anti-inflammatory agents includes biologicals such as anticytokine therapies and small molecules that block the activity of kinases. Other anti-inflammatories currently in use or under development include statins, histone deacetylase inhibitors, PPAR agonists, and small RNAs. This Review discusses the current status of anti-inflammatory drug research and the development of new anti-inflammatory therapeutics.
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