Journal
ANDROLOGIA
Volume 48, Issue 5, Pages 603-604Publisher
WILEY
DOI: 10.1111/and.12486
Keywords
creatine kinase; pentoxifylline; semen
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Funding
- Jordan University of Science and Technology
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Creatine kinase enzyme (CK) is indispensable for sperm function because it catalyses the regeneration of ATP from the chemical shuttle between creatine and creatine phosphate. Here, we measured CK activity of human spermatozoa in the presence of pentoxifylline (PF), a xanthine derivative drug primarily used to treat peripheral vascular function. Nine semen samples from different males were subjected to swim up, incubated with PF and tested for CK activity using the kinetic spectrophotometric method. The CK activity of spermatozoa significantly increased after addition of PF at 5mm compared with the control (with 0.0mm PF). Given that PF has been identified as a sperm motility enhancer and that CK is crucial for adequate sperm motion; then, the aptitude of PF to enhance sperm motility may be modulated by increasing CK activity.
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