Journal
CELL
Volume 136, Issue 4, Pages 719-730Publisher
CELL PRESS
DOI: 10.1016/j.cell.2009.01.044
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- NIH
- DFG
- EMBL
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The localization of mRNAs to subcellular compartments provides a mechanism for regulating gene expression with exquisite temporal and spatial control. Recent studies suggest that a large fraction of mRNAs localize to distinct cytoplasmic domains. In this Review, we focus on cis-acting RNA localization elements, RNA-binding proteins, and the assembly of mRNAs into granules that are transported by molecular motors along cytoskeletal elements to their final destination in the cell.
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