Journal
CELL
Volume 137, Issue 1, Pages 32-45Publisher
CELL PRESS
DOI: 10.1016/j.cell.2009.03.023
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Funding
- National Institute of Child Health and Development [R01HD04260, R01DK072301, R01DK075972]
- National Institute of Diabetes, Digestive and Kidney Disorders [F32 DK079541]
- Macular Vision Research Foundation
- Foundation for Fighting Blindness
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Cilia are complex structures that have garnered interest because of their roles in vertebrate development and their involvement in human genetic disorders. In contrast to multicellular invertebrates in which cilia are restricted to specific cell types, these organelles are found almost ubiquitously in vertebrate cells, where they serve a diverse set of signaling functions. Here, we highlight properties of vertebrate cilia, with particular emphasis on their relationship with other subcellular structures, and explore the physiological consequences of ciliary dysfunction.
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