Journal
CELL
Volume 138, Issue 1, Pages 16-18Publisher
CELL PRESS
DOI: 10.1016/j.cell.2009.06.024
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Funding
- NIGMS NIH HHS [R01 GM076536, R01 GM076536-04S1, R01 GM076536-04, R01 GM067779-04, R01 GM067779, R01 GM067779-06] Funding Source: Medline
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Many genes are toxic when overexpressed, but general mechanisms for this toxicity have proven elusive. Vavouri et al. (2009) find that intrinsic protein disorder and promiscuous molecular interactions are strong determinants of dosage sensitivity, explaining in part the toxicity of dosage-sensitive oncogenes in mice and humans.
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