Journal
DERMATOLOGY
Volume 207, Issue 3, Pages 265-268Publisher
KARGER
DOI: 10.1159/000073088
Keywords
estrogen dermatitis; intradermal test; Langerhans cells; tamoxifen
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Background: Most estrogen dermatitides are induced by local or systemic contact dermatitis where dendritic cells are central, and tamoxifen has a blocking effect on dendritic cells. Methods: We present 5 cases of estrogen dermatitis in which the clinical features were prurigo, urticaria, acneiform eruption and annular erythema. Results: Tamoxifen was effective in 3 of 4 cases. Three of 4 biopsy specimens showed the formation of Langerhans cell nests in the epidermis and hair follicles and perivascular infiltration of CD4+ and CD8+ lymphocytes in the dermis. Conclusion: These results suggest that a dendritic-cell-mediated allergic mechanism is involved in estrogen dermatitis. Copyright (C) 2003 S. Karger AG, Basel.
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