Journal
CELL
Volume 137, Issue 6, Pages 997-1000Publisher
CELL PRESS
DOI: 10.1016/j.cell.2009.05.042
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
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The APP-processing pathway is a pathological component of Alzheimer's disease (AD), but there is no consensus regarding the physiological functions of APP and its products. Two studies (Nikolaev et al., 2009; Lauren et al., 2009) link the physiological and pathological aspects of APP processing. They show that the APP products, N-APP and A beta 42, are ligands for death receptor 6 and cellular prion protein, respectively, which are important in nervous system development and synaptic suppression.
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