Journal
CELL
Volume 137, Issue 3, Pages 391-395Publisher
CELL PRESS
DOI: 10.1016/j.cell.2009.04.034
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Funding
- Medical Research Council [MC_U105178807, G0600914] Funding Source: Medline
- MRC [MC_U105178807, G0600914] Funding Source: UKRI
- Medical Research Council [MC_U105178807, G0600914] Funding Source: researchfish
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Recent findings of gene fusions in carcinomas recapitulate the discovery of chromosomal abnormalities in leukemias and sarcomas decades ago. A recurring feature of carcinoma gene fusions, in contrast to those in hematopoietic and mesenchymal malignancies, is that they result in aberrant cell signaling. This may reflect differences in the differentiation programs of these tissues.
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