Journal
CELL
Volume 136, Issue 4, Pages 688-700Publisher
CELL PRESS
DOI: 10.1016/j.cell.2009.02.001
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Funding
- Wellcome Trust
- Howard Hughes Medical Institute
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The pathway from gene activation in the nucleus to mRNA translation and decay at specific locations in the cytoplasm is both streamlined and highly interconnected. This review discusses how pre-mRNA processing, including 50 cap addition, splicing, and polyadenylation, contributes to both the efficiency and fidelity of gene expression. The connections of pre-mRNA processing to upstream events in transcription and downstream events, including translation and mRNA decay, are elaborate, extensive, and remarkably interwoven.
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