Journal
CURRENT MEDICINAL CHEMISTRY
Volume 10, Issue 21, Pages 2231-2252Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867033456747
Keywords
huperzine A; Alzheimer's disease; acetylcholinesterase; X-ray crystallography; molecular modeling
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HupA is a potent, reversible AChEI, which crosses the blood-brain barrier smoothly, and shows high specificity for AChE with a prolonged biological half-life. It has been approved as the drug for the treatment of AD in China, and marketed in USA as a dietary supplement. HupA has been the subject of investigations by an ever-increasing number of researchers since 1980's. In the last four years, HupA has been further studied in many aspects such as the chemical synthesis, structural modification, structure-activity relationship, various biological effects, and mechanisms of action. A number of papers dealing with the computational modeling and X-ray crystallographic studies of HupA-AChE complex have also been published. This review represents a comprehensive documentation of the progress in the studies on HupA during the period of 1999-2002.
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