Journal
CELL
Volume 138, Issue 4, Pages 623-625Publisher
CELL PRESS
DOI: 10.1016/j.cell.2009.08.007
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During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-throughput screen, which successfully identifies small molecules that specifically inhibit cancer stem cell proliferation through the induction of differentiation.
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