Journal
CELL
Volume 132, Issue 1, Pages 27-42Publisher
CELL PRESS
DOI: 10.1016/j.cell.2007.12.018
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [R01 CA084254-10, R01 CA109618-05, R01 CA084254, R01 CA109618] Funding Source: Medline
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Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation, development, and homeostasis. Autophagy principally serves an adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. However, in certain experimental disease settings, the self-cannibalistic or, paradoxically, even the prosurvival functions of autophagy may be deleterious. This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases.
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