Journal
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
Volume 19, Issue 8, Pages 777-782Publisher
SPRINGER
DOI: 10.1023/A:1026052715260
Keywords
algae; antibacterial effect; Fucus vesiculosus; marine bioprospecting; natural products
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An antibacterial compound was isolated from the brown alga Fucus vesiculosus. Purification consisted of extraction of plant material with 0.05% trifluoroacetic acid, concentration on a C-18 cartridge, and reverse-phase high performance liquid chromatography on a C-18 semi-preparative column. The isolated compound exhibited antibacterial activity against both the Gram-positive and the Gram-negative bacteria tested. Killing studies conducted indicated that the activity was bactericidal. The compound showed no haemolytic effect against human red blood cells. Results obtained by electrospray ionization mass spectrometry indicated that the antibacterial activity was caused by a polyhydroxylated fucophlorethol.
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