Journal
ACTA DERMATO-VENEREOLOGICA
Volume 83, Issue 6, Pages 410-413Publisher
ACTA DERMATO-VENEREOLOGICA
DOI: 10.1080/00015550310015419
Keywords
epidermis; human; regional differences; skin biopsies; stratum corneum
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Epidermal thickness and its relationship to age, gender, skin type, pigmentation, blood content, smoking habits and body site is important in dermatologic research and was investigated in this study. Biopsies from three different body sites of 71 human volunteers were obtained, and thickness of the stratum corneum and cellular epidermis was measured microscopically using a preparation technique preventing tissue damage. Multiple regressions analysis was used to evaluate the effect of the various factors independently of each other. Mean (SD) thickness of the stratum corneum was 18.3 (4.9) mum at the dorsal aspect of the forearm, 11.0 (2.2) mum at the shoulder and 14.9 (3.4) mum at the buttock. Corresponding values for the cellular epidermis were 56.6 (11.5) mum, 70.3 (13.6) mum and 81.5 (15.7) mum, respectively. Body site largely explains the variation in epidermal thickness, but also a significant individual variation was observed. Thickness of the stratum corneum correlated positively to pigmentation (p=0.0008) and negatively to the number of years of smoking (p<0.0001). Thickness of the cellular epidermis correlated positively to blood content (P=0.028) and was greater in males than in females (P<0.0001). Epidermal thickness was not correlated to age or skin type.Epidermal thickness and its relationship to age, gender, skin type, pigmentation, blood content, smoking habits and body site is important in dermatologic research and was investigated in this study. Biopsies from three different body sites of 71 human volunteers were obtained, and thickness of the stratum corneum and cellular epidermis was measured microscopically using a preparation technique preventing tissue damage. Multiple regressions analysis was used to evaluate the effect of the various factors independently of each other. Mean (SD) thickness of the stratum corneum was 18.3 (4.9) mum at the dorsal aspect of the forearm, 11.0 (2.2) mum at the shoulder and 14.9 (3.4) mum at the buttock. Corresponding values for the cellular epidermis were 56.6 (11.5) mum, 70.3 (13.6) mum and 81.5 (15.7) mum, respectively. Body site largely explains the variation in epidermal thickness, but also a significant individual variation was observed. Thickness of the stratum corneum correlated positively to pigmentation (p=0.0008) and negatively to the number of years of smoking (p<0.0001). Thickness of the cellular epidermis correlated positively to blood content (P=0.028) and was greater in males than in females (P<0.0001). Epidermal thickness was not correlated to age or skin type.
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