Journal
CELL
Volume 132, Issue 4, Pages 532-536Publisher
CELL PRESS
DOI: 10.1016/j.cell.2008.02.006
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Funding
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Medical Research Council [G19/38] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- Medical Research Council [G19/38] Funding Source: researchfish
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In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-renewal while continually presenting opportunities for lineage specification.
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