Journal
CELL
Volume 132, Issue 4, Pages 612-630Publisher
CELL PRESS
DOI: 10.1016/j.cell.2008.01.041
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Funding
- NHLBI NIH HHS [P01 HL56949] Funding Source: Medline
- NIAID NIH HHS [R01 AI069259-01] Funding Source: Medline
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Regulated movement of stem cells is critical for organogenesis during development and for homeostasis and repair in adulthood. Here we analyze the biological significance and molecular mechanisms underlying stem cell trafficking in the generation of the germline, and the generation and regeneration of blood and muscle. Comparison across organisms and lineages reveals remarkable conservation as well as specialization in homing and migration mechanisms used by mature leukocytes, adult and fetal stem cells, and cancer stem cells. In vivo trafficking underpins the successful therapeutic application of hematopoietic stem cells for bone-marrow transplant, and further elucidation of homing and migration pathways in other systems will enable broader application of stem cells for targeted cell therapy and drug delivery.
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