Journal
CELL
Volume 132, Issue 4, Pages 631-644Publisher
CELL PRESS
DOI: 10.1016/j.cell.2008.01.025
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NHLBI NIH HHS [P01 HL032262-27, R01 HL075735-06, R01 HL075735, R01 HL032259-27, P01 HL032262, R01 HL032259] Funding Source: Medline
- NIDDK NIH HHS [P30 DK049216-15, P30 DK049216] Funding Source: Medline
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Establishment and maintenance of the blood system relies on self-renewing hematopoietic stem cells (HSCs) that normally reside in small numbers in the bone marrow niche of adult mammals. This Review describes the developmental origins of HSCs and the molecular mechanisms that regulate lineage-specific differentiation. Studies of hematopoiesis provide critical insights of general relevance to other areas of stem cell biology including the role of cellular interactions in development and tissue homeostasis, lineage programming and reprogramming by transcription factors, and stage- and age-specific differences in cellular phenotypes.
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