Journal
CURRENT MEDICINAL CHEMISTRY
Volume 10, Issue 21, Pages 2317-2325Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867033456701
Keywords
biosynthesis; C-1027; calicheamicin; combinatorial biosynthesis; enediyne; polyketide synthase
Funding
- NCI NIH HHS [CA78747] Funding Source: Medline
- NIAID NIH HHS [AI51687] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA078747] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI051687] Funding Source: NIH RePORTER
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This review gives a brief account on the current status of enediyne biosynthesis and the prospective of applying combinatorial biosynthesis methods to the enediyne system for novel analog production. Methods for cloning enediyne biosynthetic gene clusters are first reviewed. A unified paradigm for enediyne biosynthesis, characterized with (a) the enediyne PKS, (b) the enediyne PKS accessory enzymes, and (c) tailoring enzymes, is then presented. Strategies and tools for novel enediyne analog production by combinatorial biosynthesis are finally discussed. The results set the stage to decipher the molecular mechanism for enediyne biosynthesis and lay the foundation to engineer novel enediynes by combinatorial biosynthesis for future endeavors.
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