Journal
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
Volume 39, Issue 8, Pages 613-617Publisher
BLACKWELL PUBLISHING ASIA
DOI: 10.1046/j.1440-1754.2003.00246.x
Keywords
individualized total parenteral nutrition; low gestational age; parenteral nutrition; pharmacoeconomic cost; standardized total parenteral nutrition
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Objective: To evaluate the difference in nutrient intakes and biochemical responses in newborn infants <33 weeks gestation who received standardized versus individualized total parenteral nutrition (TPN) regimes. Method: Comparison of nutrient intakes and daily biochemical responses in newborn infants <33 weeks gestation who received standardized regime versus those who received individualized TPN regimes from day 2 to day 7 of life. Results: Twenty-seven infants in the standardized TPN group and 31 infants in the individualized TPN group were compared. There were no statistically significant differences (P > 0.05) between the two groups in gestation, birthweight, Clinical Risk Index for Babies scores, daily TPN volume intake and biochemical responses. Infants in the standardized TPN group received less sodium (P < 0.01) and no potassium on day 2 as required, more protein (P < 0.02) every day, and more calcium and phosphate (P < 0.02 from day 4). Conclusion: There were no significant clinical and statistical differences in biochemical responses in newborn infants <33 weeks gestation who received standardized versus individualized TPN regimes during the first week of life. The economic cost of TPN provision using standardized TPN formulation was approximately 30% lower.
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