Journal
NUCLEAR MEDICINE COMMUNICATIONS
Volume 24, Issue 11, Pages 1185-1188Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00006231-200311000-00009
Keywords
Tc-99m ethyl cysteinate dimer; single photon emission computed tomography; regional cerebral blood flow; carbon monoxide poisoning
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Tc-99m ethyl cysteinate dimer (Tc-99m-ECD) brain single photon emission computed tomography (SPECT) was used to detect abnormal regional cerebral blood flow (rCBF) in patients with acute carbon monoxide (CO) poisoning. Ten patients with acute CO poisoning and no past histories of psychoneurological disorders were enrolled in this study. After oxygen treatment, all of the 10 patients were investigated using Tc-99m-ECD brain SPECT and brain computed tomography (CT) scan. Brain CT scan findings were normal in all of the 10 patients. Tc-99m-ECD brain SPECT showed the hypoperfusion lesions of the basal ganglia and brain cortex in five and seven patients, respectively. Only three of the 10 patients had normal Tc-99m-ECD brain SPECT findings. This study suggests that, in comparison with brain CT scan, Tc-99m-ECD brain SPECT is a better tool for the early detection of hypoperfusion brain lesions in acute CO poisoning in patients with normal brain CT findings. ((C) 2003 Lippincott Williams Wilkins).
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