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Knockdown Screens to Knockout HIV-1

Journal

CELL
Volume 135, Issue 3, Pages 417-420

Publisher

CELL PRESS
DOI: 10.1016/j.cell.2008.10.007

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Funding

  1. PHS [R37 CA 30488]
  2. National Cancer Institute

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Three recent screens use siRNAs to identify host genes that are critical for HIV-1 replication. These screens have uncovered hundreds of human genes not previously known to be commandeered by the virus during infection. Although some caveats remain, this screening approach opens up a new landscape of viral-host interactions for future exploration.

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