Journal
CELL
Volume 133, Issue 7, Pages 1188-1201Publisher
CELL PRESS
DOI: 10.1016/j.cell.2008.04.050
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01 GM025326-30, R01 GM044794-16, R01 GM025326-27, R01 GM025326-28, R01 GM044794-18, R01 GM044794, R01 GM-044794, R01 GM044794-17, R01 GM044794-15, R01 GM025326, R01 GM044794-14, R01 GM025326-29, R01 GM-025326, R01 GM025326-31] Funding Source: Medline
Ask authors/readers for more resources
Chromosome movement is prominent during meiosis. Here, using a combination of in vitro and in vivo approaches, we elucidate the basis for dynamic mid-prophase telomere-led chromosome motion in budding yeast. Diverse findings reveal a process in which, at the pachytene stage, individual telomere/nuclear envelope (NE) ensembles attach passively to, and then move in concert with, nucleus-hugging actin cables that are continuous with the global cytoskeletal actin network. Other chromosomes move in concert with lead chromosome(s). The same process, in modulated form, explains the zygotene bouquet'' configuration in which, immediately preceding pachytene, chromosome ends colocalize dynamically in a restricted region of the NE. Mechanical properties of the system and biological roles of mid-prophase movement for meiosis, including recombination, are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available