Journal
CELL
Volume 135, Issue 6, Pages 1004-1006Publisher
CELL PRESS
DOI: 10.1016/j.cell.2008.11.029
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The Bcl-2 family protein Bax is a key effector of apoptosis. Lovell et al. ( 2008) now describe the reconstitution and regulation in liposomes of tBid-mediated membrane penetration and oligomerization of Bax. These and other recent studies shed new light on the control of permeabilization of the mitochondrial outer membrane during apoptosis.
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