Grb10 adapter protein as regulator of insulin-like growth factor receptor signaling

Grb10 is a member of a superfamily of adapter proteins that includes Grb 10, 7, 14, and a protein of Caenorhabditis elegans called Mig 10. Grb 10 proteins are binding partners for several trans-membrane tyrosine-kinase receptors, including the insulin-like growth factor receptor (IGF-IR) and the insulin receptor (IR). Many recent reports have suggested a very important role of Grb 10 in regulating IGF-IR signaling. In this review, we will focus on the role of Grb 10 in IGF-I-induced mitogenesis and we will discuss the recent findings that show the involvement of Grb 10 in the regulation of ligand-induced ubiquitination, internalization, and stability of the IGF-IR. (C) 2003 Wiley-Liss, Inc.