4.8 Editorial Material

Clearing the path for germ cells

Journal

CELL
Volume 132, Issue 3, Pages 337-339

Publisher

CELL PRESS
DOI: 10.1016/j.cell.2008.01.023

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The chemokine SDF-1a and its receptor CXCR4b guide germ cell migration in zebrafish by activating downstream signaling events. Boldajipour et al. (2008) now report that a second SDF-1a receptor, CXCR7, is also required for guided migration but does not function as a signaling receptor, and instead sequesters SDF-1a. These results highlight the importance of ligand clearance during guided cell migration.

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