Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 22, Issue 11, Pages 810-818Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0165-9936(03)01208-1
Keywords
aptamers; aptasensors; aptazymes; biosensors; in vitro selection; SELEX
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Aptamers are artificial nucleic acid ligands that can be generated against amino acids, drugs, proteins and other molecules. They are isolated from complex libraries of synthetic nucleic acids by an iterative process of adsorption, recovery and amplification. This review described the in vitro process to obtain aptamers (SELEX). It mentions the main characteristics of these molecules (i.e. affinity, specificity and stability). Moreover, it discusses advantages over antibodies. It reports potential applications of aptamers in analytical and diagnostic assays as biocomponents of biosensors (aptasensors) and allosteric ribozymes (aptazymes). (C) 2003 Published by Elsevier B.V.
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