Journal
CELL
Volume 132, Issue 6, Pages 929-934Publisher
CELL PRESS
DOI: 10.1016/j.cell.2008.03.004
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Funding
- NEI NIH HHS [EY18244, PN2 EY018244] Funding Source: Medline
- NIGMS NIH HHS [R01 GM042694-10] Funding Source: Medline
- PHS HHS [42694, 71407] Funding Source: Medline
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The mammalian cell nucleus provides a landscape where genes are regulated through their organization and association with freely diffusing proteins and nuclear domains. In many cases, specific genes are highly dynamic, and the principles governing their movements and interchromosomal interactions are currently under intensive study. Recent investigations have implicated actin and myosin in chromatin dynamics and gene expression. Here, we discuss our current understanding of the dynamics of the interphase genome and how it impacts nuclear organization and gene activity.
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