Journal
BIOESSAYS
Volume 25, Issue 12, Pages 1201-1211Publisher
WILEY
DOI: 10.1002/bies.10362
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The final assembly of the protein synthesis machinery occurs during translation initiation. This delicate process involves both ends of eukaryotic messenger RNAs as well as multiple sequential protein-RNA and protein-protein interactions. As is expected from its critical position in the gene expression pathway between the transcriptome and the proteome, translation initiation is a selective and highly regulated process. This synopsis summarises the current status of the field and identifies intriguing open questions. (C) 2003 Wiley Periodicals, Inc.
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