Journal
CELL
Volume 135, Issue 4, Pages 594-596Publisher
CELL PRESS
DOI: 10.1016/j.cell.2008.10.033
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [R01 AI022511-23, R01 AI022511] Funding Source: Medline
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In this issue, Xu et al. (2008) provide evidence for a new mechanism of T cell receptor regulation. Prior to activation, basic residues in the cytoplasmic domain of the signaling subunits of the T cell receptor associate with the plasma membrane such that the key signaling tyrosines are sequestered in the bilayer.
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