Journal
NEUROLOGICAL SCIENCES
Volume 24, Issue 5, Pages 322-328Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-003-0183-2
Keywords
epilepsy; multiple sclerosis; EEG; magnetic resonance imaging; status epilepticus; interferon therapy
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Epileptic seizures occur more frequently in multiple sclerosis (MS) patients than in the general population. We evaluated clinical, electroencephalographic (EEG) and magnetic resonance imaging (MRI) findings, as well as EEG-MRI correlations and the response to antiepileptic drugs (AEDs) in 270 consecutive patients with definite MS referred to our Department from 1995 to 2002. Thirteen (4.8%) subjects experienced epileptic seizures. In four cases, seizures manifested within 1-2 years (early-onset), and in six cases within 8-23 years (late-onset) of MS diagnosis. Seizures were usually partial with secondary generalization. Thus, acute symptomatic seizures occurred in three cases. Epilepsy usually appeared late in the course of disease, although a single episode or a cluster of seizures can represent the onset symptom or a relapse of MS. Prognosis of epilepsy during the course of MS is usually good but the choice of AEDs remains a matter of debate.
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