Journal
CELL
Volume 133, Issue 7, Pages 1135-1137Publisher
CELL PRESS
DOI: 10.1016/j.cell.2008.06.003
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Funding
- NIEHS NIH HHS [ES14811, R01 ES014811-04, R01 ES014811, R01 ES014811-02S1, R01 ES014811-05S1, R01 ES014811-03, R01 ES014811-05, R01 ES014811-02, R01 ES014811-01A1] Funding Source: Medline
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A recent study in Nature (Isalan et al., 2008) has examined the effects of systematically adding new transcriptional interactions in the bacterium Escherichia coli. Surprisingly, the majority of the engineered connections have no effect on growth, and in some cases the new connections enhance fitness. These findings reveal insights into the robustness and evolvability of gene networks.
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