Non-stroke neurological syndromes associated with antiphospholipid antibodies: evaluation of clinical and experimental studies

Although many types of neurological disorders and events have been described in association with antiphospholipidantibodies (aPL) and the antiphospholipidsyndrome (APS), only ischaemic stroke is reasonably well established and accepted as a diagnostic criterion for the syndrome. We propose to evaluate, classify and rank the association of other neurological manifestations as possible, probable, or definite according to the data available from clinical studies and animal models. By these criteria, none of the neurological disorders or events such as epilepsy, psychiatric disease, dementia, transverse myelitis, multiple sclerosis-like disease, chorea, migraine, Guillian-Barre syndrome, and sensory-neural hearing loss, can be definitely associated with aPL or APS.