4.1 Article

The synthesis of a pyrazol analogon of porphobilinogen with the help of the Mukaiyama aldol reaction

Journal

CHIMIA
Volume 57, Issue 10, Pages 601-606

Publisher

SWISS CHEMICAL SOC
DOI: 10.2533/000942903777678812

Keywords

biomimetic synthesis; Mukaiyama aldol reaction; porphobilinogen; silyl enol ether

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The synthesis of a pyrazol analogon of porphobilinogen is described. The Mukaiyama crossed aldol reaction is the key step of our approach. The retrosynthetic analysis follows the mechanism for the biosynthesis of porphobilinogen initially proposed by Shemin.

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