Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 7, Issue 1, Pages 28-37Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op0202179
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The Fmoc/TAEA and Bsmoc/TAEA methods for the rapid, continuous solution synthesis of peptide segments are shown to be applicable to the gram-scale synthesis of short peptides as well as, for the first time, to the synthesis of a relatively long (22-mer) segment, (hPTH 13-34). In the latter case the crude product was of significantly greater purity than a sample obtained via a solid-phase protocol. The Bsmoc methodology was optimized by a new technique involving filtration of the growing partially deprotected peptide at each coupling-deprotection cycle through a short column of silica gel.
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