Green heterocycle synthesis, isochromenones and artemidin

Organic transformations in near critical water, generated in heated stainless steel pressure reactors or microwave irradiated Teflon or glass pressure reactors, yield a green synthesis of isochromen-1-ones or isocourmarins.(1) A synthesis of the isochromen-1-one artemidin using a combination of synthetic microwave and commercial microwave equipment is presented.