Journal
CELL CYCLE
Volume 2, Issue 4, Pages 293-295Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.2.4.427
Keywords
cell cycle; gene expression; cyclin D; CDK; p21waf1; transcription; viral cyclins; herpes
Categories
Funding
- LLigue Departementale Pour la Recherche Sur le Cancer
- Agence Nationale de Recherches sur le SIDA
- Cancer & Solidarity Foundation
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It is now clear that viral cyclins have new functions that provide infected cells with additional stimuli that further activate cell cycle progression. These proteins resist the actions of cell cycle inhibitors, extend the range of cdk substrates, and as a consequence favor cell proliferation and virus propagation. Like some of the endogeneous cyclins, these viral proteins might have also important functions during transcriptional regulation. Binding to transcriptional regulator might enable the virus to target multiple functions of transcriptional activation and cell growth. Whether these effects have any physiological relevance during viral replication or cell transformation will be an important issue to address.
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