Journal
EXPERIMENTAL GERONTOLOGY
Volume 38, Issue 1-2, Pages 61-69Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0531-5565(02)00160-2
Keywords
normal aging; learning and memory; humans; monkeys; rats; hippocampal plasticity; ensemble dynamics
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Funding
- NATIONAL INSTITUTE ON AGING [R01AG003376, R56AG003376, R21AG018890] Funding Source: NIH RePORTER
- NIA NIH HHS [AG18890, AG03376] Funding Source: Medline
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Cognitive alterations occur over the lifespan of every species studied and have been quantified carefully in humans, other primates and rodents. Correspondingly, changes in hippocampal function have been associated with a number of observed memory impairments across species. It appears that humans, alone, show Alzheimer's disease-like cognitive and neural pathology spontaneously. Thus, a comparison of normal age-related changes in cognition in other animals can help disambiguate the boundary between normal and pathological states of aging in humans. Another important contribution made from studying aging in non-human species is the ability to examine, in more detail, the basic neural mechanisms that may be responsible for brain aging in these species. So far, most of the functional neurobiological studies have been conducted in the aged rat. We propose that the link between rodent and human work can be made much stronger by combining neurophysiological and behavioral investigation of normal aging in the non-human primate. (C) 2002 Elsevier Science Inc. All rights reserved.
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