Journal
CELL CYCLE
Volume 2, Issue 6, Pages 573-575Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.2.6.578
Keywords
DNA replication; ORC; heterochromatin; origin firing; silencing
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Considerable evidence connects heterochromatin or silenced chromatin with the Origin Recognition Complex (ORC) which is needed for initiation of DNA replication.(1-7) In this review we consider biological forces that might be served by this connection. The prevailing view in the literature is that ORC recruits heterochromatin. This seems paradoxical because a replication initiator, ORC, would be recruiting factors which seem to oppose replication by forming inaccessible chromatin structures. Here we suggest a different view, that heterochromatin recruits ORC to facilitate replication of hard-to-replicate heterochromatic regions. We consider how existing data can be reconciled with this viewpoint, and we consider the biological predictions that arise from this perspective.
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